Centre for Nanotechnology

CENTRE FOR NANOTECHNOLOGY

About: Centre for Nanotechnology (CNT) established as an interdisciplinary research centre in the campus of Vishnu Institute of Pharmaceutical Education & Research (VIPER), Narsapur, Telangana in the year 2020. The aim of the centre is to initiate and pursue research activities in areas related to nanotechnology and nanoscale phenomena and collaborative research with other institutes and industries. It will benefit the medical research by making pharmaceuticals more efficacious and by decreasing their adverse side-effects. 

Nano technology in Drug delivery: One application of nanotechnology in medicine currently being developed involves employing nanoparticles to deliver drugs to specific types of cells (such as cancer cells). Particles are engineered so that they are attracted to diseased cells, which allow direct treatment of those cells. This technique reduces damage to healthy cells in the body and allows for earlier detection of disease.

Nanotechnology has been applied to diverse medical fields such as oncology and cardiovascular medicine. Indeed, nanotechnology is being used to refine discovery of biomarkers, molecular diagnostics, and drug discovery and drug delivery.

CNT deals with emerging new technologies for developing customized solutions for drug delivery systems. The drug delivery system positively impacts the rate of absorption, distribution, metabolism, and excretion of the drug or other related chemical substances in the body. In addition to this the drug delivery system also allows the drug to bind to its target receptor and influence that receptor’s signaling and activity. Pharmaceutical nanotechnology embraces applications of nanoscience to pharmacy as nanomaterials, and as devices like drug delivery, diagnostic, imaging and biosensor.

Nanotechnology is having an impact on several aspects of food science, from how food is grown to how it is packaged. Companies are developing nanomaterials that will make a difference not only in the taste of food, but also in food safety, and the health benefits that food delivers.

We at CNT working on various disciplines like Bio pharmaceutics, Nano drug delivery system and Food science and to understand the current global state of Nanotechnology in drug discovery.  The Centre has well sophisticated and well-equipped Nano technology facility

Activities

1. Formulation of nano-formulations such as nanoparticles, liposomes and nano-emulsions are used in the pharmaceutical industry for drug delivery.

2. Formulation of nanosuspensions for external use

a) Papers published

1. Prasanna Kumar Desu, Bisheswar Karmakar, Vanitha Kondi, Optimizing formulation of green tea extract-loaded chitosan nanogel, Biomass Conversion and Biorefinery,2022; Publisher: Springer.

2. Singh, A.R., Desu, P.K., Nakkala, R.B., Vanitha kondi, Kesharwani, P."Nanotechnology-based approaches applied to nutraceuticals" Drug Delivery and Translational Research, 2021; Publisher: Springer

3. Desu PK, Lanka H, Thippeswamy L, Reddy VA, Keshava DP, Soujanya C, Satya BL, Anusha R. Formulation and Evaluation of Fluvastatib Loaded Nanoparticles by Nanoprecepitration Method. International Journal of Drug Delivery Technology. 2022;12(3):1166-1170.

4. Sandhya Rani M, Srinivas L. Development of Solid Lipid Nanoparticles with Letrozole for Breast Cancer Treatment: in-vitro and in-vivo evaluation. (2022). Journal of Pharmaceutical Negative Results, 1159-1166. DOI: 10.47750/pnr.2022.13.S01.142

5. Monirul Islam M, Hemmanahalli Ramesh V, Durga Bhavani P, Goudanavar PS, Naveen NR, Ramesh B, Fattepur S, NarayanappaShiroorkar P, Habeebuddin M, Meravanige G, Telsang M, Sreeharsha N. Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing. Drug Deliv. 2022 Dec;29(1):3370-3383. doi: 10.1080/10717544.2022.2144963. 

6. Sandhya Rani Mandadi and Lankalapalli Srinivas (2023). Synthesis and characterization of letrozole-loaded polymer based nanoparticulate formulations for treating breast cancer. Ann. Phytomed., 12(1):310-317. http://dx.doi.org/10.54085/ap.2023.12.1.30.

b) Patents (Both granted and published)

1. A novel assay for drug stability testing based on nanotechnology thereof (Application number: 202441098164)

2. Identification of trace contaminants in drug products using nanotechnology thereof (Application number: 202441098222)

c)Extramural grants received

1. “Socio-economic upliftment of Schedule cast community through cultivation of Spirulina biomass and commercial exploitation” from DST.

2. “Development and Characterization of letrozole loaded polymer based nanoparticulate formulations to induce programmed cellular death in breast cancers: in-vitro & amp; in-vivo evaluation studies” from ICMR

3. “Socio-economic upliftment or rural community through cultivation of spirulina biomass and commercial exploitation” from UBA