Drug Resistance in Cancer

Centre for Molecular cancer research (CMCR) established as an interdisciplinary research centre in the campus of Vishnu Institute of Pharmaceutical Education & Research (VIPER), Narsapur, Telangana in the year 2015. The aim of the centre is to bridge the gap between Pharmaceutical and life science research and also to bring the multilayered process of cancer drug discovery on to single platform. The focus of the research Centre will be to create and Screen compounds that are purpose-built to interrupt specific biochemical processes while avoiding harm to normal cellular functions.
We at CMCR working on various disciplines like Medicinal chemistry, Computational chemistry, and Cancer biology to understand the current global state of drug discovery. The Centre for Molecular Cancer Research is playing a transformative role on this campus and well beyond our borders in the field of cancer research. The Centre has well sophisticated Cell culture facility and well equipped Life science research facilities along with Computational & Medicinal chemistry laboratories.  CMCR got recognized with ISO 9001:2015 for “Provide cell culture based in-vitro testing, analytical and formulation development services”

Trust Areas Research:
• Molecular Mechanisms of Nitric Oxide (NO) in Cancer Progression, Signal Transduction, drug influx and efflux process in Pg-P and MDR over expressed resistant cancer cells.
• Nanoparticle based drug delivery in cancer therapy and its role in overcoming drug resistance.
• Aurora-Kinase inhibitors as anticancer agents

Facility for Cell Culture:
Cultured animal and human cells have been used in biomedical research for many decades.  Cultured cells are commonly used in toxicology experiments to identify the biological effects of chemicals and drugs (mechanisms of action) and in screening assays to determine the relative toxicity of substances. The goal of in-vitro toxicology is to develop a range of cellular and organotypic models and assays capable of replacing animals in various toxicity tests that are used to predict toxic effects to humans from exposure to chemicals and product ingredients. The cell culture facility provides a centralized facility for growth of animal cells in culture to meet the requirements of the experimental research methodologies. CMCR has various mammalian cell lines for carrying out drug screening. CMCR equipped with following instruments.

Services:
• Cutting edge research on cancer biology and Medicinal chemistry.
• Contract Research Services for academicians, researchers and industries etc.
• Student training services and workshops.
• Involvement of students on various novel research activities on Cancer biology and Medicinal Chemistry.
• Here, we will provide all kind of in-vitro Anti-Cancer Screening services. 

Strength of CMCR:
• Well Equipped and sophisticated Cell culture facility.
• In-silico Medicinal Chemistry & Drug discovery facility.
• Cellular & Molecular biology experimental facility.
• In-vitro Fluorescent studies on Cancer cell lines.
• PCR studies.
• Advanced SDS-PAGE & Agarose Electrophoresis units
• Gel doc mage acquisition system.
• Micro and macro centrifuges.
• Other advanced Equipment's related to Cancer biology.
• Schrodinger small molecule drug discovery suite.